孫慧慧，工學(xué)博士，副研究員，碩士生導(dǎo)師，兼任山東省食品科學(xué)技術(shù)學(xué)會(huì)第四屆理事。主持包括國(guó)家自然科學(xué)基金青年基金、中國(guó)博士后科學(xué)基金、山東省自然科學(xué)基金博士基金等在內(nèi)共計(jì)7項(xiàng)課題，并作為科研骨干參與了國(guó)家重點(diǎn)研發(fā)計(jì)劃“藍(lán)色糧倉(cāng)科技創(chuàng)新”重點(diǎn)專(zhuān)項(xiàng)1項(xiàng)。累計(jì)發(fā)表論文20余篇，其中以第一作者/通訊作者在Comprehensive Reviews in Food Science and Food Safety、Journal of Agricultural and Food Chemistry、International Journal of Biological Macromolecules等領(lǐng)域內(nèi)權(quán)威期刊發(fā)表論文12篇；獲授權(quán)發(fā)明專(zhuān)利6項(xiàng)，其中第一發(fā)明人4項(xiàng)；參編著作《海洋食品酶工程》1部。榮獲神農(nóng)中華農(nóng)業(yè)科技獎(jiǎng)科學(xué)研究類(lèi)成果一等獎(jiǎng)（第五完成人，2021）。
主要研究領(lǐng)域?yàn)槲⑸锩概c生物催化轉(zhuǎn)化在海洋食品中的應(yīng)用，主要包括酶的基因發(fā)掘和高效表達(dá)，催化機(jī)制解析和理性分子改造，生化反應(yīng)過(guò)程優(yōu)化與調(diào)控等研究。
代表性論文
[1] H.H. Sun, L. Zhao, X.Z. Mao, R. Cao*, Q. Liu. Identification of a key loop for tuning transglycosylation activity in the substrate-binding region of a chitosanase. Journal of Agricultural and Food Chemistry. 2023, 71, 5585-5591.
[2] N. Cao, G.L. Xia, H.H. Sun*, L. Zhao, R. Cao, H. Jiang, X.Z. Mao, Q. Liu. Characterization of a galactose oxidase from Fusarium odoratissimum and its application in the modifification of agaros. Foods. 2023, 12, 603.
[3] Y.M. Cheng, Z.Y. Li, H.H. Sun*, L. Zhao, Z. Liu, R. Cao, Q. Liu, X.Z. Mao. Immobilization of chitosanase on magnetic nanoparticles: Preparation characterization and properties. Journal of Ocean University of China. 2022, 21, 1381-1388.
[4] 孫慧慧, 楊國(guó)淞, 程伊夢(mèng), 李昭悅, 趙玲, 曹榮*，劉淇. 海洋寡糖的生物活性研究進(jìn)展[J]. 食品科學(xué). 2022, 43(13): 276-284.
[5] H.H. Sun, L. Gao, C.H. Xue, X.Z. Mao*. Marine-polysaccharide degrading enzymes: Status and prospects. Comprehensive Reviews in Food Science and Food Safety. 2020, 19, 2767-2796.
[6] H.H. Sun, G.S. Yang, R. Cao*, X.Z. Mao, Q. Liu. Expression and characterization of a novel glycoside hydrolase family 46 chitosanase identified from marine mud metagenome. International Journal of Biological Macromolecules. 2020, 159, 904-910.
[7] H.H. Sun, X.Z. Mao, N. Guo, L. Zhao, R. Cao*, Q. Liu. Discovery and characterization of a novel chitosanase from Paenibacillus dendritiformis by phylogeny-based enzymatic product specificity prediction. Journal of Agricultural and Food Chemistry. 2018, 66, 1139-1145.
[8] H.H. Sun, R. Cao, L.H. Li*, L. Zhao, Q. Liu. Cloning, purification and characterization of a novel GH46 family chitosanase, Csn-CAP, from Staphylococcus capitis. Process Biochemistry. 2018, 75, 146-151.
